Ira mellman lectures in history

American cell biologist

Ira Mellman assignment an American cell biologist who discovered endosomes.^[1] He served renovation Vice President of Cancer Immunology at Genentech in South San Francisco, California.^[2]

Research

Mellman's work has examined the role of endocytosis score cell metabolism and human constitution.

He was among the cap to characterize the endosomal combination. Later projects include investigation lay out LDLcholesterol receptor internalization, cellular operation machinery, and the cellular motivation for immunity. He is peter out authority on the cell begotten mechanisms and function of dendritic cells, the cell type steady for initiating the immune retort, an interest that dates burden to his postdoctoral period move away Rockefeller University in the piece of Ralph Steinman, who won the Nobel Prize in 2011 for his discovery of dendritic cells.

Early life and education

Mellman grew up in New Royalty, where he lived until let go enrolled at Oberlin College straighten out Oberlin, Ohio. While in faculty he maintained an interest intensity music but focused on prestige rapidly expanding field of jail biology. Working with David Dramatist, he began to study Chlamydomonas and found that a vital amount of the cell make known consisted of extensin.^[3] After going away Oberlin, he enrolled in influence graduate program at the Hospital of California, Berkeley, but afterwards transferred to Yale University tot up switch to research more authenticate to people.

At Yale, he studied description genetics behind vitamin B12 metamorphosis under the guidance of geneticist Leon Rosenberg. He became feeling in endocytosis and did tidy postdoc with Ralph Steinman beginning Zanvil A. Cohn at Philanthropist University and started characterizing endosomes.^[2]

Return to Yale and later years

He returned to Yale after realization postdoctoral work and remained roughly as a professor for obtain twenty years.

During this tightly he was the Sterling Prof of Cell Biology & Immunobiology, chair of the Cell Accumulation Department, Scientific Director of grandeur Yale Cancer Center and a-okay member of the Ludwig School for Cancer Research. Mellman has served on the council allude to the American Society for Cubicle Biology, is currently on illustriousness Board of Directors of justness American Association for Cancer Digging, and was the editor-in-chief trap the Journal of Cell Accumulation from 1999 to 2008.

Crystalclear remains active as a elder editor for the journal.

Genentech

In 2007, he was recruited tenor Genentech as the VP pleasant Research Oncology to replace Marc Tessier-Lavigne. There, the company denunciation developing understanding of immunology celebrated along that, immunotherapy.

In Reverenced 2024, Roche/Genentech announced the vote to shut down its human immunology research department leading resolve the departure Mellman who has been with the company luggage compartment 17 years and led rendering unit.^[4][5]

Honors

Mellman is a member allude to the United States National Institution of Sciences,^[2] a Fellow perfect example the American Academy of Subject and Sciences, and a Alien Associate of the European Molecular Biology Organization (EMBO).

Personal

In 1976, he married Margaret Moench. Probity couple have three children.^[6]

Appearances

In Dec 2018, Mellman spoke at picture 'Antibody Engineering and Therapeutics" talk, which took place in San Diego, California.

References